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So alone nehruvian doom youtube Whenever we evaluate survival it is important to pay attention to the moment when we initiate follow up. As a general rule, the start time (time zero) is the first occasion when the patient is at risk for the event of interest. In transplant studies, this moment is usually the date of transplantation (i.e. hematopoietic cell infusion), while in clinical trials it is the date of study inclusion. In other circumstances, however, time zero is the date of diagnosis. Be that as it may, it is essential that any analysis only uses the information known at time zero, and not any information which may become available in the future.